Nostradamus: The Last Prophecy is set in 16th century Provence, in a country
ravaged by religious wars and devastated by the plague.

It has been three years since Catherine de MÚdicis' rule as regent came to
an end, but she still holds the reins of power, making her the target of
repeated attacks from the French nobility. One day in March 1566, when she
realises that she has fallen victim to a terrible curse, she turns to her
doctor and astrologer, Michel de Nostre-Dame, better known as Nostradamus.
Unfortunately, the famous prophet is too old and weak to take on such a
mission alone. Refusing to abandon his queen in her hour of need, he sends
his daughter Madeleine in his place. However, there is no such thing as
women astrologers, let alone women doctors in medieval times. To be accepted
as such, the young woman must go in disguise and assume her younger
brother's identity, Caesar, who is away for some time.

Alternating between Madeleine the young woman and Madeleine disguised as
Caesar, players are plunged into a thriller where political scheming and
ancestral prophecies are intertwined. The game begins as an initiatory
adventure in the footsteps of her father, the prophet and astrologer, before
creating all the suspense of a detective novel: from one murder to another,
players make their way through a test-riddled forensic investigation.
Following in the same vein as The Secrets of Da Vinci: The Forbidden
Manuscript, Nostradamus: The Last Prophecy is an historical adventure game
in which players have to solve a series of riddles and puzzles inspired by
the works of Nostradamus, taking them through the worlds of astrology,
medicine and medicinal plants.

Though the game does not offer two fundamentally different paths,
"transforming" the main character gives players a unique alternative by
allowing them to assume another identity, change sex (their appearance in
any case) and use it to their advantage when interacting with other
characters.